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D-RIBOSE & The Triad of Metabolic Cardiology

D-RIBOSE & The Triad of Metabolic Cardiology

*D-Ribose is a five-carbon monosaccharide that is vital for the cellular synthesis of ATP (adenosine triphosphate), the genetic materials DNA and RNA, certain vitamins and cofactors, and second messenger cell signaling compounds.

Since the ribose available in the human diet is negligible, the body relies on the ribose synthesized by the cells. *While every cell in the body has the ability to make ribose, the metabolic pathway used in ribose synthesis is slow and rate limited. In times of metabolic stress the body’s inability to produce ribose limits ATP synthesis, restricts the formation of important cellular compounds, and delays tissue recovery.

Researchers began to study ribose in the 1930s but did not begin to understand its importance until the 1950s when research techniques became sophisticated enough to investigate the intricate metabolic role of ribose in various body tissues. In the mid-1980s, John Foker, M.D., Ph.D., a University of Minnesota cardiovascular surgeon and biochemist, began pioneering research proving the rate limiting impact of ribose availability on recovery from cardiac ischemia. This research triggered a cascade of scientific investigation that has expanded to many tissue and physiological processes. This research continues today.

Physiological Role of Ribose


The science of cellular bioenergetics takes into account all the metabolic mechanisms associated with energy supply and demand and considers how this energy is used to fuel cellular and tissue function. Any discussion on bioenergetics needs to consider both the concentration of energy in the cellular energy pool and the cell’s ability to efficiently recycle its energy supply.

ATP is the “energy currency” of the cell. ATP provides the power all cells need to function. Metabolic stress drains this cellular energy. *Many physiological conditions, including strenuous exercise, hard work, drug interactions, and many diseases, deplete the concentration of substrates in the cellular energy pool, leaving tissue energy starved. *Ribose is essential for stressed cells to restore the volume of energy substrates needed to maintain a healthy cellular energy pool. *Ribose is the fundamental building block of ATP and without ribose the process of energy synthesis grinds to a halt.

Ribose is made naturally from glucose via the pentose phosphate pathway. This complex metabolic process is controlled by the gate keeping enzymes glucose-6-phospate dehydrogenase (G-6-Pdh) and 6-phosphogluconate dehydrogenase (6-PGdh). Because the activities of these enzymes are poorly expressed in most body tissues, a delay in ribose synthesis limits cellular energy recovery.

*Stressed cells simply cannot make energy fast enough to keep pace with demand. Frequent bouts of high-intensity exercise or chronic metabolic stress mean that cells can never fully recharge energy pools on their own. Ribose administration significantly accelerates energy recovery, allowing cells to conserve energy substrates and rebuild depleted energy pools.

What Ribose Can Do:

Athletes and Exercise. For serious athletes, recovery time is paramount. High-intensity exercise drains muscle energy pools, contributing to delayed onset muscle soreness (DOMS), exertional fatigue, loss of peak performance, and tissue damage. *The fundamental role of ribose in energy synthesis and salvage is to accelerate tissue energy recovery, helping to restore the physiological condition of muscle, reduce cell damage, limit free radical formation, and protect the heart and muscles from the rigors of strenuous exercise. *Athletes recover more quickly, allowing them to train longer and harder, raise their level of conditioning, and optimize performance.

For those who exercise more sporadically, prolonged muscle soreness and fatigue can be debilitating. Recovery from a weekend run, a long cycle ride, or even hard work in the yard can take days, limiting a desire for the frequent exercise needed to promote cardiovascular health and weight control. *Ribose shortens recovery time, reduces muscle soreness, and limits the onset or severity of fatigue. *Faster recovery, less fatigue, and reduced muscle pain promotes exercise, benefiting overall health.

Muscle Health. Energy depletion unleashes a cascade of cellular reactions that contributes to muscle pain. Energy starved muscle cells are unable to manage their calcium load, causing them to become stiff and tense, putting even more pressure on cellular energy reserves.  Cellular calcium retention forces potassium efflux that activates membrane associated pain receptors, called nociceptors, contributing to muscle pain and reducing exercise tolerance. Pain further exacerbates muscle tension, using even more pain. *By fueling ATP synthesis, and restoring the cellular energy charge, ribose helps reverse this energy depletion-pain cycle, reducing muscle pain, over coming fatigue, and enhancing quality of life.

Myalgia can also be associated with the poor expression of muscle enzymes associated with energy metabolism. Deficiencies in myoadenylate deaminase or the enzymes associated with glycogen storage and utilization depletes cellular energy pools. *Ribose administration replaces this lost energy, helping to overcome the pain, soreness, stiffness, and fatigue associated with poor energy metabolism, allowing sufferers to lead more normal, active lives.

Cardiovascular Health. Cardiovascular disease remains the number one killer of Americans. More people die from cardiovascular disease than from the next four causes of death combined. A recent Mayo Clinic study reported that 28.1% of the population over age 45 (men and women) suffers from symptoms of diastolic heart dysfunction and 20% over age 40 are at risk for contracting congestive heart failure (CHF) as a result. More than half of this at-risk population is unaware of their precarious condition. This CHF risk exceeds the lifetime risk of many commonly screened conditions and is associated with a significant increase in all-cause mortality. Prevention of CHF through preclinical treatment is recommended in the CHF guidelines.

Cardiac energy metabolism plays a pivotal role in heart function. Congestive heart failure, ischemic heart disease, and cardiomyopathy deplete cardiac energy stores by 30% or more, contributing to chronically depressed heart function.

*Ribose administration accelerates ATP synthesis, helping supply the crucial energy reserves needed to preserve cardiovascular health and wellness or recover from hypoxic insult. Clinical data shows that ribose supplementation can increase the heart’s hypoxic threshold, improve diastolic heart function, increase exercise tolerance and quality of life in heart patients, and restore oxygen utilization efficiency.

*Ribose is the only compound used by the body to maintain the concentration of cellular energy reserves. And unless the volume of cellular energy substrates is adequate to provide the chemical driving force for cellular function, no level of ATP turn over efficiency can meet the cell’s demand for energy.

*Bioenergy RIBOSE is safe, stable, and has a low flavor profile, so it won’t impact the taste, texture, or shelf. Ribose is all natural and highly purified. RIBOSE is certified kosher.


Ribose is safe for use in dietary supplements in doses up to 20-grams per day. A pre-market safety notification has been submitted to the U.S. Food and Drug Administration according to guidelines established by the Dietary Supplement Health Education Act (DSHEA).

*RIBOSE is all natural and completely safe. Doses of up to 60-grams per day have been taken without significant side effects. There are reports of mild diarrhea and lightheadedness when fasting subjects consumed ribose in individual doses greater then 10-grams. These side effects of Bioenergy RIBOSE are not unique.

There are no known interactions between RIBOSE and any food, dietary supplement, or over-the-counter or prescription drug.

Currently patent protected applications range from increasing tissue energy (U.S. patent number 6,159,942), to reducing soreness, stiffness, and cramping in muscle (U.S. patent number 6,159,943), to recovery from ischemia (U.S. patent number 4,719,201), to treating fibromyalgia (U.S. patent number 6,703,370), to raising the hypoxic threshold of stressed tissue (U.S. patent number 6,218,366), and more.

The Triad of Metabolic Cardiology

Traditionally, heart disease has been treated with pharmaceuticals, surgery or both. Science now shows us that there’s another way to think about heart disease and its prevention and treatment. It focuses on “The Triad of Metabolic Cardiology” -three compounds that are essential to building and maintaining energy levels in hearts and skeletal muscles. D-Ribose, or simply ribose, is the part of the Triad that is used to actually create energy.

As one noted cardiologist states: “Patients are looking for less invasive, safer and lower cost treatments for all medical conditions, including heart disease, and metabolic cardiology offers it.” Each element of the Triad plays a different but complementary role, giving hearts and muscles the metabolic support they need to build energy more quickly and use it more efficiently.

The Triad of Metabolic Cardiology includes:

  • D-Ribose, the primary compound used to create the energy molecule itself and sustain cellular energy metabolism.
  • Coenzyme Q10 or CoQ10, the spark that ignites the energy process and keeps it running efficiently.
  • L-Carnitine, delivering fuel into the cells’ energy furnace and removing cellular toxins.

*Ribose is the only compound that can effectively facilitate energy synthesis in the body, while L-Carnitine and Coenzyme Q10 help the body use existing energy stores more efficiently. “Ribose can improve the effect of these energy supplements by keeping the energy pool at full capacity, allowing them to do their work more effectively. Without adequate levels of energy facilitated by ribose, they cannot be fully effective. This synergy is essential to restore energy drained by heart disease and to protect hearts and muscles from the stress of oxygen deprivation or overwork.

Natural Bio Health offers The Triad of Metabolic Cardiology in the correct form and the correct amount.


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