The number one fear expressed by women interested in HRT is breast cancer.  A great deal of this fear has really been caused by the way in which the magazines and headlines have portrayed it.  However, what causes the increased risk of breast cancer is not bioidentical estradiol but the synthetic PROGESTIN (which is NOT progesterone). According to the Journal of National Cancer Institute, adding a progestin to HRT increases the risk of breast cancer at 29% over baseline.  *Bioidentical progesterone decreases the risk.

*We also decrease the risk by ensuring that estradiol is  going down the 2-hydroxy estradiol pathway. Indole-3-Carbinol, DIM 9di-indolmethane and various other compounds found in cruceriferous vegetables will favor the 2-hydroxyestrone pathway so ensure your estradiol is going down the correct and safe pathway.

Joseph R. NBH, MD, FACOG, AACS, AACG

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