Melatonin CR

Sleep, Brain, Immune health

90 Tablets

Serving Size: 1 Tablet

Storage: Keep closed in a cool, dry place.

Formulated to Exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, and preservatives.

Categories , ,


Sleep, Brain, Immune health

Clinical Applications:

  • Support Synchronization of the Body’s Daily Biorhythms*
  • Support Restful Sleep*
  • Direct and Indirect Antioxidant Support*
  • Support Healthy Immune Response*
  • Support Brain Health*

*Melatonin CR is a vegetarian formula with a biphasic delivery system that releases melatonin quickly and then steadily. Melatonin is naturally produced in the pineal gland in response to changes in light exposure; it helps promote healthy sleep patterns as well as antioxidant and immune activities. Melatonin CR can support these functions by helping to maintain normal levels of melatonin in the body.*








Melatonin is a neurohormone produced from tryptophan by the pineal gland when it is stimulated by darkness. While melatonin regulates many other hormones; its primary function appears to be regulation of the body’s daily and annual biological rhythms.*

Oral supplementation has been shown to have some benefit with regard to time to sleep onset, total sleep time, and sleep efficiency.[1] Noteworthy advantages over pharmaceutical sleep aids are improved performance upon wakening and the absence of memory impairment. [2,3] According to studies, daytime melatonin supplementation by travelers crossing time zones and/or shift workers also promotes sleep.*[4]

Research has shown that melatonin not only fights free radicals during sleep, but also stimulates the body’s own antioxidant systems. For example, it reduced harmful oxidized cholesterol (LDL) in post- menopausal women.[5] Melatonin’s antioxidant capacity also accounts for its role as a neuroprotectant. By delivering antioxidant benefits and correcting the circadian rhythm, melatonin could support cognitive function.*[6,7]

A decrease in plasma melatonin correlates with a decline in immune function in some individuals beginning around the age of sixty. Interestingly, lymphoid cells are an important physiological source of melatonin in humans.The hormone appears to stimulate production of T helper (TH) cells and their release of interleukin-2, gamma interferon and opiod peptides.[8] Considering the decline in melatonin synthesis with age, exogenous supplementation with the hormone has long been of interest in anti-aging protocols.*[9,10]

The addition of pyridoxine in this formula supports the biosynthesis of melatonin and may also enhance dream recall.*

The biphasic delivery system consists of 1mg of melatonin in the coating solution and the remainder in the tablet core. The melatonin in the coating solution is immediately released upon digestion. The melatonin in the tablet core is released over a 6-hour period. The tablet core contains a tableting agent, hydroxypropyl methylcellulose that works by forming a gel layer when hydrated. This gel layer acts as a diffusion barrier to control the rate of release of the melatonin in the tablet core. As the tablet travels through the intestine, the gel layer slowly erodes to release the melatonin, which then is available for absorption in the intestine.*

*These statements have not been evaluated by the Food and Drug Administration.


This product is not intended to diagnose, treat, cure, or prevent any disease.

  1. Brzezinski A, Vangel MG, Wurtman RJ, et al. Effects of exogenous melatonin on

sleep: a meta-analysis. Sleep Med Rev.2005;9:41-50. [PMID: 15649737]

  1. Paul MA, et al.Melatonin and zopiclone as pharmacologic aids to facilitate crew

rest. Aviat Space Environ Med. 2001 Nov;72(11):974-84. [PMID: 11718517]

  1. Wesensten NJ, Balkin TJ, Reichardt RM et al. Daytime sleep and performance

following a zolpidem and melatonin cocktail. Sleep. 2005;28:93-103. [PMID:


  1. Srinivasan V, et al. Jet lag: therapeutic use of melatonin and possible application

of melatonin analogs. Travel Med Infect Dis. 2008 Jan-Mar;6(1-2):17-28.

[PMID: 18342269]

  1. Wakatsuki A, et al. Melatonin inhibits oxidative modification of low-density

lipoprotein particles in normolipidemic post-menopausal women. J Pineal Res.

2000;28:136-142 [PMID: 10739299]

  1. Peck JS, et al. Cognitive effects of exogenous melatonin administration in

elderly persons: a pilot study. Am J Geriatr Psychiatry. 2004;12:432-436.

[PMID: 15249281]

  1. Asayama K, Yamadera H, Ito T, et al. Double blind study of melatonin effects on

the sleep-wake rhythm, cognitive and noncognitive functions in Alzheimer type

dementia. J Nippon Med Sch. 2003;70:334-341. [PMID: 12928714]

  1. Cardinali DP, Melatonin and the immune system in aging.

Neuroimmunomodulation. 2008;15(4-6):272-8. [PMID: 19047804]

  1. Armstrong SM, Redman JR. Melatonin: A chronobiotic with anti-aging

properties? Med Hypotheses 1991;34: 300-9 [PMID: 1865836]

  1. Rozencwaig R, Grad BR, Ochoa J. The role of melatonin and serotonin in aging.

Med Hypotheses 1987;23: 337-52 [PMID: 2889131]

  1. Miyamoto A, Serum melatonin kinetics and long-term melatonin treatment

for sleep disorders in Rett syndrome. Brain Dev. 1999 Jan;21(1):59-62 [PMID:


  1. Arendt J. Safety of melatonin in long-term use. J Biol Rhythms 1997;12:673-

681 [PMID: 9406044]

  1. Voordouw BC, Melatonin and melatonin-progestin combinations alter

pituitary-ovarian function in women and can inhibit ovulation. J Clin Endocrinol

Metab. 1992 Jan;74(1):108-17. [PMID: 1727807]

  1. Abd-Allah AR, et al. Effect of melatonin on estrogen and progesterone receptors

in relation to uterine contraction in rats. Pharmacol Res. 2003 Apr;47(4):349-

54 [PMID: 12644393]

Additional references available upon request

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