Progesterone is one of the most important, if not the most important hormone produced by women. It is always produced with ovulation for the purpose of preparing the uterine lining to accept a fertilized ovum and by the placenta early and throughout the pregnancy. Without adequate levels of progesterone, the embryo will not survive. The reason is the embryo contains two difference genetic patterns, male and female. The male chromosomes represents a foreign protein that the body wants to reject. It is progesterone that protects the embryo from being rejected by the uterus and is responsible for maintaining the pregnancy throughout the nine months.
A deficiency of progesterone not only fails to protect the embryo (miscarriages, infertility) but also is responsible for many other symptoms and conditions to include PMS (premenstrual syndrome), endometriosis, fibroid tumors, PCOS, weight gain, migraine headaches and many other issues. Progesterone is always indicated after menopause along with a replacement dose of estradiol. It has a protective mechanism against, uterine cancer, breast cancer, colon cancer and cancer of the rectum. Even in the early premenopausal years, when the production of progesterone is decreasing, the symptoms can be markedly reduced with the addition of progesterone. Progesterone has little or no side effects since it is naturally produced by the ovaries and placenta. The most common side effects are bloating and water retention, a temporary condition.